Abstract Introduction: Tuberculosis (TB) is a major global health issue, with millions of people affected each year. Timely detection and appropriate management of TB are essential to reduce its spread and associated morbidity and mortality. In this study, the authors aimed to observe the prevalence of common clinical symptoms among diagnosed TB patients and their duration. The study findings can provide valuable insights for healthcare providers in managing TB patients and improving treatment outcomes. Methods: This observational cross-sectional study was conducted at the Department of Mdicine, Pabna Medical College, Pabna. Study was done from January 2021 to December 2021. Result: Most participants were aged 31-50 years, with 37.93% falling into the 41-50 age range. 58.62% were male, while 41.38% were female. Housewives (37.93%), laborers/farmers (34.48%), and students (12.07%) made up the majority of participants. Bronchial asthma (86.21%) was the most prevalent comorbidity, followed by hypertension (36.21%) and diabetes mellitus (17.24%). The majority of participants (63.79%) fell within the normal BMI range of 18.5-24.9. Cough (94.83%) and fever (74.14%) were the most common symptoms. Among the 43 participants with on and off fever, 53.49% had been experiencing fever for more than 2 weeks up to 1 month. Among the 55 participants with continuous cough, 60% had been experiencing cough for more than 2 weeks up to 1 month. Conclusion: The study found that most participants were between the ages of 31-50 years, with a majority being male. Bronchial asthma was the most common comorbidity observed. The majority of participants had a normal BMI, and cough was the most prevalent symptom. The duration of fever and cough among TB patients was found to be prolonged, with a majority experiencing symptoms for more than 2 weeks up to 1 month. Early diagnosis and treatment are essential to prevent the progression of the disease and reduce the duration of symptoms.